Oral medicine: 17. radiolucencies and radio-opacities. d. antral disease

From Volume 41, Issue 4, May 2014 | Pages 370-372

Authors

David H Felix

BDS, MB ChB, FDS RCS(Eng), FDS RCPS(Glasg), FDS RCS(Ed), FRCPE

Postgraduate Dental Dean, NHS Education for Scotland

Articles by David H Felix

Jane Luker

BDS, PhD, FDS RCS, DDR RCR

Consultant and Senior Lecturer, University Hospitals Bristol NHS Foundation Trust, Bristol

Articles by Jane Luker

Crispian Scully

CBE, DSc, DChD, DMed (HC), Dhc(multi), MD, PhD, PhD (HC), FMedSci, MDS, MRCS, BSc, FDS RCS, FDS RCPS, FFD RCSI, FDS RCSEd, FRCPath, FHEA

Bristol Dental Hospital, Lower Maudlin Street, Bristol BS1 2LY, UK

Articles by Crispian Scully

Article

David H Felix
Jane Luker
Crispian Scully

Specialist referral may be indicated if the Practitioner feels:

  • The diagnosis is unclear;
  • A serious diagnosis is possible;
  • Systemic disease may be present;
  • Unclear as to investigations indicated;
  • Complex investigations unavailable in primary care are indicated;
  • Unclear as to treatment indicated;
  • Treatment is complex;
  • Treatment requires agents not readily available;
  • Unclear as to the prognosis;
  • The patient wishes this.
  • Antral disease

    Paranasal sinuses are air-filled cavities in the dense portions of the bones of the skull lined with a ciliated mucosa, the mucus from which drains via openings (ostia) into the nose. The main sinuses are frontal, ethmoid, sphenoid and maxillary. Their main disorders are inflammatory and neoplastic. This section focuses on the maxillary sinus (antrum).

    The floor of the maxillary antrum will be visualized in maxillary intra-oral films and in DPTs – where the medial and posterior wall can also be assessed (Figure 1).

    Figure 1. Anatomy of the maxillary antrum imaged in a DPT.

    Sinusitis

  • Definition: inflammation of the sinus mucosa. Sinusitis most commonly affects the ethmoid sinuses, which then causes a secondary maxillary sinusitis. As a result of later development of the sinuses, sphenoid sinusitis is unusual in children under age 5 years and frontal sinusitis is unusual before age 10. Maxillary sinusitis is subdivided into acute and chronic sinusitis, the differential being a 3-month time period.
  • Prevalence (approximate): common; (15–20% of the population at some point);
  • Age mainly affected: any;
  • Gender mainly affected: M = F.
  • Aetiopathogenesis: cilia damage (eg tobacco smoke exposure), or impaired mucociliary clearance as when ostia are obstructed (eg allergic or infective rhinitis, foreign bodies, polyps). A change in sinus air pressure may cause pain (eg from ostia obstruction, increased mucus production, or air pressure changes such as flying or diving)(Table 1).

  • Allergic (vasomotor) rhinitis and nasal polyps;
  • Viral upper respiratory tract infection (URTI);
  • Diving or flying;
  • Nasal foreign bodies;
  • Periapical infection of maxillary posterior teeth;
  • Oro-antral fistula;
  • Prolonged endotracheal intubation.
  • Bacteria are most commonly the cause, and incriminated are:

  • In acute sinusitis: Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis. Staphylococcus aureus and Streptococcus pyogenes may also be involved.
  • In chronic sinusitis, also anaerobes, especially Porphyromonas (Bacteroides);
  • In some circumstances, Gram-positive cocci and bacilli as well as Gram-negative bacilli may also be found – especially after prolonged endotracheal intubation, and in HIV/AIDS. In many immunocompromised persons, fungi (mucor, aspergillus or others) may be involved and, in cystic fibrosis, Pseudomonas aeruginosa, Acinetobacter baumannii and Enterobacteriaceae are often implicated.
  • Diagnostic features

    History

    Symptoms can include nasal drainage (rhinorrhea or post nasal drip), nasal blockage, the sensation of swelling in nose or sinuses, ear symptoms, pain in teeth worse on biting or leaning over, halitosis, headache, fever, cough, malaise, etc (Table 2). Symptoms are typically less severe in chronic sinusitis.


    Location Location of pain Other features
    Maxillary Cheek and/or upper teeth Tenderness over antra
    Frontal Over frontal sinuses Tenderness of sides of nose
    Ethmoidal Between eyes Anosmia, eyelid swelling
    Sphenoidal Ear, neck, and at top or centre of head

    Clinical features

    There may be nasal turbinate swelling, erythema and injection (dilated blood vessels), mucus, sinus tenderness, allergic ‘shiners’ (dark circles around eyes), pharyngeal erythema, otitis, etc.

    Diagnosis is from the history, plus sinus tenderness and dullness on transillumination. Nasendoscopy can visualize the mucosal surface inside the maxillary or sphenoid sinus in over 50% of patients. Nasal cytology with a rhinoprobe may help and ear examination is important.

    Acute sinusitis is diagnosed and treated clinically and does not require imaging. If symptoms persist after 10 days of treatment, CT is recommended when the results may affect management. Plain films are not recommended as the findings are usually non-specific. Differentiating between sinusitis and URTI is difficult. Antral radio-opacities in children under age 6 years can be difficult to evaluate since they are seen in up to 50%. In adults, a sinus radio-opacity may be due to mucosal thickening or a mucous retention cyst (Figures 2 and 3) but a fluid level is highly suggestive of acute sinusitis. Corticated opacities occurring in the maxillary antrum indicate that the aetiology of the opacity is extrinsic to the antrum, eg an apical radicular cyst (Figure 4). MRI may be recommended if there are complications such as peri-orbital infection, or to rule out malignancy.

    Figure 2. Half DPT (left side) showing antral anatomy and dome-shaped soft tissue opacity of a mucous retention cyst.
    Figure 3. (a) Coronal CT of maxilla showing right-sided benign mucous retention cyst. (b) Axial CT of (a).
    Figure 4. Section of DPT showing antral opacity with corticated margin indicating aetiology extrinsic to the antrum, in this case an apical radicular cyst associated with the upper right first molar.

    It may sometimes be necessary to perform a needle aspiration sinus to confirm the diagnosis, and sample infected material to culture to determine what micro-organism is responsible.

    In patients with recurrent or recalcitrant sinusitis, cystic fibrosis and immunodeficiencies may need to be excluded.

    Management

    Acute sinusitis resolves spontaneously in about 50%, but analgesics are often indicated and other therapies may be required, especially if symptoms persist or there is a purulent discharge.

    Intranasal steroids are helpful in many patients, although studies evaluating the efficacy have not been conclusive. Antihistamines are used for patients with significant allergic symptoms. Oral decongestants help, but typically may be used for 3–7 days only as longer use may cause rebound and rhinitis medicamentosa. Guaifenesin helps thin and increase clearance of secretion. Buffered saline lavage may help in clearing secretions. Hot steam is often helpful.

    Antibiotic treatment for at least two weeks in acute sinusitis and at least three weeks in chronic sinusitis is commonly required. Treatment for acute sinusitis is amoxicillin, ampicillin or co-amoxiclav (erythromycin if penicillin-allergic), or a tetracycline such as doxycycline or clindamycin. Chronic sinusitis responds better to drainage by functional endoscopic sinus surgery (FESS), plus antimicrobials (metronidazole with amoxicillin, erythromycin, clindamycin or a cephalosporin). Open procedures including the classical Caldwell-Luc operation are generally outmoded.

    Neoplasms

  • Definition: usually squamous carcinoma
  • Prevalence (approximate): rare;
  • Age mainly affected: older people;
  • Gender mainly affected: M > F.
  • Aetiopathogenesis: the only identified predisposing factors are smoking and occupational exposure to wood dust.
  • Diagnostic features

    These tumours can remain undetected until late. When they infiltrate branches of the trigeminal nerve they cause maxillary pain. As the tumour expands the effects of expansion and infiltration of adjacent tissues become apparent as intra-oral alveolar swelling, ulceration of the palate or buccal sulcus; swelling of the cheek; unilateral nasal obstruction often associated with a blood-stained discharge; obstruction of the nasolacrimal duct with epiphora; hypo-or anaesthesia of the cheek; proptosis and ophthalmoplegia consequent on invasion of the orbit and trismus from infiltration of the muscles of mastication.

    Diagnosis is supported by endoscopy, radiography (Figures 5a and b), magnetic resonance imaging and biopsy.

    Figure 5. (a) DPT showing radiological features of a malignancy of the right antrum – opacity and bony destruction of the floor of the antrum. (b) Section of an occipito-mental radiograph, showing loss of lateral wall of the right maxillary antrum, a feature that is highly suspicious of malignant disease.

    Management

    Combinations of surgery and radio-chemotherapy are usually required.

    Prognosis is poor with a < 30% 5-year survival.