References

Stoopler ET, Sollecito TP, Chen SY. Amyloid deposition in the oral cavity: a retrospective study and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003; 95:674-680 https://doi.org/10.1067/moe.2003.136
Westermark P. Localized AL amyloidosis: a suicidal neoplasm?. Ups J Med Sci. 2012; 117:244-250 https://doi.org/10.3109/03009734.2012.654861
Dobson M, Wright A, White S, Macluskey M. Localised oral amyloidosis in the context of oral epithelial dysplasia: literature review and report of two cases. Oral Surg. 2022; 15:333-339 https://doi.org/10.1111/ors.12619
Muchtar E, Dispenzieri A, Magen H Systemic amyloidosis from A (AA) to T (ATTR): a review. J Intern Med. 2021; 289:268-292 https://doi.org/10.1111/joim.13169
Khan MF, Falk RH. Amyloidosis. Postgrad Med J. 2001; 77:686-693 https://doi.org/10.1136/pmj.77.913.686
Memari F, Jahandideh H, Moghtader K, Amini-Harandi A. Narrowing of the upper airway due to amyloidosis: A case report. J Clin Med Res. 2011; 3:52-56
Li Y, Liu N, Xu Y Widespread purple bulla-like masses of the oral mucosa. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012; 114:552-557 https://doi.org/10.1016/j.oooo.2011.11.007
Babburi S, B R, Rv S, V A, Srivastava G. Amyloidosis of the tongue-report of a rare case. J Clin Diagn Res. 2013; 7:3094-3095 https://doi.org/10.7860/JCDR/2013/7028.3865
Foli A, Palladini G, Caporali R The role of minor salivary gland biopsy in the diagnosis of systemic amyloidosis: results of a prospective study in 62 patients. Amyloid. 2011; 18:80-82 https://doi.org/10.3109/13506129.2011.574354029
Deng J, Chen Q, Ji P Oral amyloidosis: a strategy to differentiate systemic amyloidosis involving the oral cavity and localized amyloidosis. Oral Dis. 2019; 25:670-675 https://doi.org/10.1111/odi.12870
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Amyloidosis of the oral cavity: a case report

From Volume 50, Issue 8, September 2023 | Pages 690-692

Authors

Parnyan Ashtari

Department of Oral Medicine and Department of Head and Neck and Oral Pathology, Guy's and St Thomas' NHS Foundation Trust. London

Articles by Parnyan Ashtari

Barbara Carey

MB BCh BAO BDS NUI BA FDS (OM) RCS (Eng) FFDRCSI (Oral Medicine), FHEA

Consultant in Oral Medicine, Guy’s Dental Hospital, Great Maze Pond, London SE1 9RT, UK

Articles by Barbara Carey

Lisette Collins

Department of Head and Neck and Oral Pathology, Guy's and St Thomas' NHS Foundation Trust, London

Articles by Lisette Collins

Rui Albuquerque

LMD, MS, DAS, PhD, PGCME, FHEA, FDS RCS(OM)

Birmingham Dental Hospital/School of Dentistry, University of Birmingham, 5 Pebble Mill Road, Birmingham B5 7EG, UK

Articles by Rui Albuquerque

Abstract

Although oral manifestations of amyloidosis are rare, it is important to exclude systemic involvement in patients who present with amyloidosis involving the oral cavity. Improved understanding of the oral manifestations of amyloidosis and the additional investigations required can lead to timely diagnosis and subsequent management. Treatment of localized forms of amyloidosis include resection, biologics, laser therapy and corticosteroids.

CPD/Clinical Relevance: Understanding the oral manifestations of amyloidosis can lead to timely diagnosis and management.

Article

Localized or systemic amyloidosis results from the abnormal folding of proteins, forming insoluble amyloid fibrils with subsequent deposition in various tissues and organs.1 Based upon the specific protein form that is deposited, it is classified as:

Localized amyloidosis occurs most commonly whereby the amyloid protein is restricted to a particular organ or tissue and results in deposition of AL (L stands for light chain, the protein that mutates and causes the disorder) protein.2 In systemic AL amyloidosis, previously termed primary amyloidosis, the AL deposits are located in any, or all, of the viscera, connective tissue and blood vessel walls. It is usually secondary to benign low-grade monoclonal gammopathy.3 Reactive systemic AA (serum amyloid A protein) amyloidosis, formerly known as secondary amyloidosis, occurs as a complication of chronic infections (for example tuberculosis) and inflammatory conditions (e.g. rheumatoid arthritis and Crohn's disease). It is characterized by an increased production of AA (serum amyloid A) protein.4 Hereditary systemic amyloidosis is rare and a result of autosomal dominant diseases in which there is production of amyloid fibrils from inherited variant proteins, such as transthyretin, gelsolin and apolipoprotein A-1 and fibrinogen.5

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