References

Holmstrup P, Plemons J, Meyle J. Non-plaque induced gingival diseases. J Periodontol. 2018; 89:S28-S45
Wright HJ, Chapple IL, Matthews JB. TGF-beta isoforms and TGF-beta receptors in drug-induced and hereditary gingival overgrowth. J Oral Pathol Med. 2001; 30:281-289
Wright HJ, Chapple IL, Cooper p, Matthews JB. Platelet-derived growth factor (PDGF) isoform and PDGF receptor expression in drug-induced gingival overgrowth and hereditary gingival fibrosis. Oral Dis. 2006; 12:315-323
Bolivar I, Whiteson K, Stadelmann B Bacterial diversity in oral samples of children in Niger with acute noma, acute necrotizing gingivitis, and healthy controls. PLoS Negl Trop Dis. 2012; 6 https://doi.org/10.1371/journal.pntd.0001556
Melnick SL, Roseman JM, Engel D, Cogen RB. Epidemiology of acute necrotizing ulcerative gingivitis. Epidemiol Rev. 1988; 10:191-211
Hu J, Kent P, Lennon JM, Logan LK. Acute necrotising ulcerative gingivitis in an immunocompromised young adult. BMJ Case Rep. 2015; 16
Dufty J, Gkranias N, Petrie A Prevalence and treatment of necrotizing ulcerative gingivitis (NUG) in the British Armed Forces: a case-control study. Clin Oral Invest. 2017; 21:1935-1944
Rowland RW. Necrotizing ulcerative gingivitis. Ann Periodontol. 1999; 4:65-73
Wade AB, Mirza RB. The relative effectiveness of sodium peroxyborate and hydrogen peroxide in treating acute ulcerative gingivitis. Dent Practitioner. 1964; 14:185-187
Loesche W, Grossman NS. Periodontal disease as a specific, albeit chronic, infection: diagnosis and treatment. Clin Microbiol Rev. 2001; 14:727-752
Duckworth R, Waterhouse JP, Britton DE Acute ulcerative gingivitis. A double-blind controlled clinical trial of metronidazole. Br Dent J. 1966; 120:599-602
Malek R, Gharibi A, Khlil N, Kissa J. Necrotizing ulcerative gingivitis. Contemp Clin Dent. 2017; 8:496-500
Arduino PG, Porter SR. Herpes simplex virus type 1 infection: overview on relevant clinico-pathological features. J Oral Pathol Med. 2008; 37:107-121
Chauvin PJ, Ajar AH. Acute herpetic gingivostomatitis in adults: a review of 13 cases, including diagnosis and management. J Can Dent Assoc. 2002; 68:247-251
Eisen D. The clinical characteristics of intraoral herpes simplex virus infection in 52 immunocompetent patients. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998; 86:432-437
Tateishi K, Toh Y, Minigawa H, Tashiro H. Detection of herpes simplex virus (HSV) in the saliva from 1000 oral surgery outpatients by the polymerase chain reaction and virus isolation. J Oral Pathol Med. 1994; 23:80-84
Scott DA, Coulter WA, Biagioni PA Detection of herpes simplex virus type 1 shedding in the oral cavity by polymerase chain reaction and enzyme-linked immunosorbent assay at the prodromal stage of recrudescent herpes labialis. J Oral Pathol Med. 1997; 26:305-309
Rajlawat Pemberton MN A paucity of cases. Br Dent J. 2007; 203
Stanberry LR, Cunningham AL, Mindel A Prospects for control of herpes simplex virus disease through immunization. Clin Infect Dis. 2000; 30:549-566
Kaye S, Choudhary A. Herpes simplex keratitis. Prog Retin Eye Res. 2006; 25:355-380
Amir J, Harel L, Smetana Z, Varsano I. Treatment of herpes simplex gingivostomatitis with aciclovir in children: a randomised double blind placebo controlled study. BMJ. 2007; 314:1800-1803
Nasser M, Fedorowicz Z, Khoshnevisan MH, Shahiri Tabarestani M. Acyclovir for treating primary herpetic gingivostomatitis. Cochrane Database Syst Rev. 2008; (4)
Macleod RI, Ellis JE. Plasma cell gingivitis related to the use of herbal tooth-paste. Br Dent J. 1989; 166:375-376
Timms MS, Sloan P. Association of supraglottic and gingival idiopathic plasmacytosis. Oral Surg Oral Med Oral Pathol. 1991; 71:451-453
Gargiulo AV, Ladone JA, Ladone PA, Toto PD. Case report: plasma cell gingivitis A. CDS rev. 1995; 88:22-23
Sanadhya S, Brown R, Basile J Plasma cell gingivitis due to cosmetics related iodopropynyl butylcarbamate (IPBC) allergy in a teenage female patient masking as desquamative gingivitis. Oral Surg Oral Med Oral Pathol Oral Radiol. 2019; 128:e89-e90 https://doi.org/10.1016/j.oooo.2019.02.229
Joshi C, Shukla P. Plasma cell gingivitis. J Indian Soc Periodontol. 2015; 19:221-223
White J, Sainuddin S, Doumpiotis D. Plasma cell gingivitis – does it still exist?. BJOMS. 2017; 55 https://doi.org/10.1016/j.bjoms.2017.08.235
Carey B, Joshi S, Abdelghani A The optimal oral biopsy site for diagnosis of mucous membrane pemphigoid and pemphigus vulgaris. Br J Dermatol. 2020; 182:747-753 https://doi.org/10.1111/bjd.18032
Orlowski WA, Bressman E, Doyle JL, Chassens AI. Chronic pemphigus vulgaris of the gingiva. J Periodontol. 1983; 54:685-689
Schmidt E, Kasperkiewicz M, Joly P. Pemphigus. Lancet. 2019; 394:882-894
Hirschfeld J, Higham J, Chatzistavrianou D Systemic disease or periodontal disease? Distinguishing causes of gingival inflammation: a guide for dental practitioners. Part 1: immune-mediated, autoinflammatory, and hereditary lesions. Br Dent J. 2019; 227:961-966
Abasq C, Mouquet H, Gilbert D ELISA testing of anti-desmoglein 1 and 3 antibodies in the management of pemphigus. Arch Dermatol. 2009; 145:529-535
Mays JW, Carey BP, Posey R. World Workshop of Oral Medicine VII: a systematic review of immunobiologic therapy for oral manifestations of pemphigoid and pemphigus. Oral Dis. 2019; 25:S111-S121
Schmidt E, Zillikens D. Pemphigoid diseases. Lancet. 2013; 381:320-332
Setterfield J, Shirlaw P, Kerr-Muir M Mucous membrane pemphigoid: a dual circulating antibody response with IgG and IgA signifies a more severe and persistent disease. Br J Dermatol. 1998; 138:602-610
Sklavounou A, Laskaris G. Frequency of desquamative gingivitis in skin diseases. Oral Surg Oral Med Oral Pathol. 1983; 56:141-144
Rashid H, Lamberts A, Diercks GFH Oral lesions in autoimmune bullous diseases: an overview of clinical characteristics and diagnostic algorithm. Am J Clin Dermatol. 2019; https://doi.org/10.1007/s40257-019-00461-7
Chan LS, Ahmed AR, Anhalt GJ The first international consensus on mucous membrane pemphigoid: definition, diagnostic criteria, pathogenic factors, medical treatment and prognostic indicators. Arch Dermatol. 2002; 138:370-379
Heelan K, Walsh S, Shear NH. Treatment of mucous membrane pemphigoid with rituximab. J Am Acad Dermatol. 2013; 69:310-311
Roopashree MR, Gondhalekar RV, Shashikanth MC Pathogenesis of oral lichen planus – a review. J Oral Pathol Med. 2010; 39:729-734
Kurago ZB. Etiology and pathogenesis of oral lichen planus: an overview. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016; 122:72-80
Liu S, Yao S, Wei W Hepatitis C virus and lichen planus: a reciprocal association determined by a meta-analysis. Arch Dermatol. 2009; 145:1040-1047
Lodi G, Pellicano R, Carrozzo M. Hepatitis C virus infection and lichen planus: a systematic review with meta-analysis. Oral Dis. 2010; 16:601-612
Petti S, Rabiei M, De Luca M, Scully C. The magnitude of the association between hepatitis C virus infection and oral lichen planus: meta-analysis and case control study. Odontology. 2011; 99:168-178
Ion DI, Setterfield JF. Oral lichen planus. Prim Dent J. 2016; 5:40-44
Andreasen JO. Oral lichen planus. 1. A clinical evaluation of 115 cases. Oral Surg Oral Med Oral Pathol. 1968; 25:31-42
Liakopoulou A, Rallis E. Bullous lichen planus – a review. J Dermatol Case Rep. 2017; 11:1-4
Scully C, el Kom M. Lichen planus: review and update on pathogenesis. J Oral Pathol. 1985; 14:431-458
Scully C, Porter SR. The clinical spectrum of desquamative gingivitis. Semin Cutan Med Surg. 1997; 16:308-313
Eisen D. The clinical features, malignant potential, and systemic associations of oral lichen planus: a study of 723 patients. J Am Acad Dermatol. 2002; 46:207-214
Canto AM, Muller H, Freitas RR, Santos PS. Oral lichen planus (OLP): clinical and complementary diagnosis. An Bras Dermatol. 2010; 85:669-675
Gandolfo S, Richiardi L, Carrozzo M Risk of oral squamous cell carcinoma in 402 patients with oral lichen planus: a follow-up study in an Italian population. Oral Oncol. 2004; 40:77-83
Patton DW, Ferguson MM, Forsyth A, James J. Oro-facial granulomatosis: a possible allergic basis. Br J Oral Maxillofac Surg. 1985; 23:235-242
Sweatman MC, Tasker R, Warner JO, Ferguson MM, Mitchell DN. Oro-facial granulomatosis. Response to elemental diet and provocation by food additives. Clin Allergy. 1986; 16:331-338
Sanderson J, Nunes C, Escudier M Oro-facial granulomatosis: Crohn's disease or a new inflammatory bowel disease?. Inflamm Bowel Dis. 2005; 11:840-846
Grave B, McCullough M, Wiesenfeld D. Orofacial granulomatosis-a 20-year review. Oral Dis. 2009; 15:46-51
McCartan BE, Healy CM, McCreary CE Characteristics of patients with orofacial granulomatosis. Oral Dis. 2011; 17:696-704
Hullah EA, Escudier MP. The mouth in inflammatory bowel disease and aspects of orofacial granulomatosis. Periodontology. 2000 2019; 80:61-76
Campbell H, Escudier M, Patel P Distinguishing orofacial granulomatosis from Crohn's disease: two separate disease entities?. Inflamm Bowel Dis. 2011; 17:2109-2115
Fitzpatrick L, Healy CM, McCartan BE Patch testing for food-associated allergies in orofacial granulomatosis. J Oral Pathol Med. 2011; 40:10-13
Campbell HE, Escudier MP, Patel P Review article: cinnamon- and benzoate-free diet as a primary treatment for orofacial granulomatosis. Aliment Pharmacol Ther. 2011; 34:687-701
Al-Johani KA, Moles DR, Hodgson TA Orofacial granulomatosis: clinical features and long-term outcome of therapy. J Am Acad Dermatol. 2010; 62:611-620
Mignogna MD, Pollio A, Leuci S Clinical behaviour and long-term therapeutic response in orofacial granulomatosis patients treated with intralesional triamcinolone acetonide injections alone or in combination with topical pimecrolimus 1%. J Oral Pathol Med. 2013; 42:73-81
van der Waal RI, Schulten EA, van der Meij EH Cheilitis granulomatosa: overview of 13 patients with long-term follow-up – results of management. Int J Dermatol. 2002; 41:225-229
Mignogna MD, Fedele S, Lo Russo L Effectiveness of small-volume, intralesional, delayed-release triamcinolone injections in orofacial granulomatosis: a pilot study. J Am Acad Dermatol. 2004; 51:265-268
Fedele S, Fung PP, Bamashmous N Long-term effectiveness of intralesional triamcinolone acetonide therapy in orofacial granulomatosis: an observational cohort study. Br J Dermatol. 2014; 170:794-801
Hegarty A, Porter Hodgson T Thalidomide for the treatment of recalcitrant oral Crohn's disease and orofacial granulomatosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003; 95:576-585
Targan SR, Hanauer SB, van Deventer SJ A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease. Crohn's Disease cA2 Study Group. N Engl J Med. 1997; 337:1029-1035
Mahadevan U, Sandborn WJ. Infliximab for the treatment of orofacial Crohn's disease. Inflamm Bowel Dis. 2001; 7:38-42

A Review of Non-plaque-related Gingival Conditions. Part One: Genetic/Developmental Disorders, Specific Infections and Inflammatory and Immune Conditions

From Volume 48, Issue 3, March 2021 | Pages 178-184

Authors

Melanie Simms

BDS, MFDS RCPS(Glasg), PGCert (Dent Ed)

StR Oral Medicine, University Dental Hospital, Cardiff

Articles by Melanie Simms

Michael Lewis

PhD, FDSRCPS, FDSRCS, FRCPath, FFGDP(UK), FHEA

Professor of Oral Medicine, School of Dentistry, Cardiff University CF14 4XY, UK

Articles by Michael Lewis

Abstract

The dental gingivae are a unique part of the oral anatomy and an integral part of the periodontal tissues. Although the vast majority of abnormalities affecting the gingival tissues are due to a simple inflammatory reaction directly related to the presence of dental plaque, a range of non-plaque-related conditions also occur due to either local or systemic factors. Such factors include developmental abnormalities, the presence of malignancy and manifestations of underlying systemic conditions. Recognition and diagnosis of non-plaque-related gingival disease is essential for comprehensive dental health care.

CPD/Clinical Relevance: This paper provides a review of the spectrum of non-plaque-related conditions that can affect the dental gingivae.

Article

The dental gingivae are a unique part of the oral anatomy, forming an integral part of the periodontal structures. The majority of changes that affect the gingivae are directly due to the presence of dental plaque; however, the gingivae can also be affected by a wide range of non-plaque-related conditions, some of which are part of normal anatomy, and others that may represent sinister pathology or a manifestation of a systemic disorder. As part of a routine examination of the oral soft tissues, dental practitioners are likely to encounter non-plaque-related gingival conditions and should know how to appropriately manage them. Part one of this two-part review discusses genetic/developmental disorders, specific infections and inflammatory and immune conditions affecting the gingival tissues.

At the 2017 World Workshop on the Classification of Periodontal and Peri-implant Diseases and Conditions, an updated classification system for non-plaque-induced gingival diseases was introduced, categorizing these mucosal abnormalities by their aetiology (Table 1).1

Register now to continue reading

Thank you for visiting Dental Update and reading some of our resources. To read more, please register today. You’ll enjoy the following great benefits:

What's included

  • Up to 2 free articles per month
  • New content available