References

Melzack R, Wall PD Pain mechanisms: a new theory. Science. 1965; 150:(3699)971-979
International Association for the Study of Pain (IASP). 1994. http://www.iasp-pain.org/AM/Template.cfm?Section=Pain_Defi
Flor H, Elbert T, Knecht S, Wienbruch C, Pantev C, Birbaumer N Phantom-limb pain as a perceptual correlate of cortical reorganization following arm amputation. Nature. 1995; 375:(6531)482-484
Woolf CJ What is this thing called pain?. J Clin Invest. 2010; 120:(11)3742-3744
Woolf CJ Novel analgesic development: from target to patient or patient to target?. Curr Opin Investig Drugs. 2008; 9:(7)694-695
Puretic MB, Demarin V Neuroplasticity mechanisms in the pathophysiology of chronic pain. Acta Clinica Croatica. 2012; 51:(3)425-429
Locker D, Grushka M The impact of dental and facial pain. J Dent Res. 1987; 66:(9)1414-1417
Hargreaves KM Orofacial pain. Pain. 2011; 152:(Suppl)S25-S32
Okeson JP The classification of orofacial pains. Oral Maxillofac Surg Clin N Am. 2008; 20:(2)133-144
Dworkin SF, Burgess JA Orofacial pain of psychogenic origin: current concepts and classification. J Am Dent Assoc. 1987; 115:(4)565-571
Benoliel R, Eliav E, Sharav Y Classification of chronic orofacial pain: applicability of chronic headache criteria. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010; 110:(6)729-737
Washington DC: National Academy of Sciences; 2011
Sessle BJ Peripheral and central mechanisms of orofacial inflammatory pain. Int Rev Neurobiol. 2011; 97:179-206
Curatolo M, Arendt-Nielsen L, Petersen-Felix S Central hypersensitivity in chronic pain: mechanisms and clinical implications. Phys Med Rehab Clin N Am. 2006; 17:(2)287-302
Gottschalk A, Smith DS New concepts in acute pain therapy: preemptive analgesia. Am Fam Physician. 2001; 63:(10)1979-1985
Iwata K, Imamura Y, Honda K, Shinoda M Physiological mechanisms of neuropathic pain: the orofacial region. Int Rev Neurobiol. 2011; 97:227-250
Petho G, Reeh PW Sensory and signaling mechanisms of bradykinin, eicosanoids, platelet-activating factor, and nitric oxide in peripheral nociceptors. Physiol Rev. 2012; 92:(4)1699-1775
Vincent K, Warnaby C, Stagg CJ, Moore J, Kennedy S, Tracey I Brain imaging reveals that engagement of descending inhibitory pain pathways in healthy women in a low endogenous estradiol state varies with testosterone. Pain. 2013; 154:(4)515-124
Howard MA, Krause K, Khawaja N, Massat N, Zelaya F, Schumann G Beyond patient reported pain: perfusion magnetic resonance imaging demonstrates reproducible cerebral representation of ongoing post-surgical pain. PLoS One. 2011; 6:(2)
Mogil JS Pain genetics: past, present and future. Trends in genetics (TIG). 2012; 28:(6)258-266
Diatchenko L, Slade GD, Nackley AG, Bhalang K, Sigurdsson A, Belfer I Genetic basis for individual variations in pain perception and the development of a chronic pain condition. Hum Mol Genet. 2005; 14:(1)135-143
Aneiros-Guerrero A, Lendinez AM, Palomares AR, Perez-Nevot B, Aguado L, Mayor-Olea A Genetic polymorphisms in folate pathway enzymes, DRD4 and GSTM1 are related to temporomandibular disorder. BMC Med Genet. 2011; 12
Solovieva S, Leino-Arjas P, Saarela J, Luoma K, Raininko R, Riihimaki H Possible association of interleukin 1 gene locus polymorphisms with low back pain. Pain. 2004; 109:(1–2)8-19
Baumann P, Broly F, Kosel M, Eap CB Ultrarapid metabolism of clomipramine in a therapy-resistant depressive patient, as confirmed by CYP2 D6 genotyping. Pharmacopsychiatry. 1998; 31:(2)
Kim YH, Back SK, Davies AJ, Jeong H, Jo HJ, Chung G TRPV1 in GABAergic interneurons mediates neuropathic mechanical allodynia and disinhibition of the nociceptive circuitry in the spinal cord. Neuron. 2012; 74:(4)640-647
Karppinen J, Daavittila I, Noponen N, Haapea M, Taimela S, Vanharanta H Is the interleukin-6 haplotype a prognostic factor for sciatica?. Eur J Pain. 2008; 12:(8)1018-1025
Waxman SG Polymorphisms in ion channel genes: emerging roles in pain. Brain. 2010; 133:(9)2515-2518
Cavalcante Felix FH, Fontenele JB Neurogenetics can help turn pain concepts more objective. Pain Med. 2009; 10:(6)1147-1148
Davis KD, Taylor SJ, Crawley AP, Wood ML, Mikulis DJ Functional MRI of pain- and attention-related activations in the human cingulate cortex. J Neurophysiol. 1997; 77:(6)3370-3380
Derbyshire SW, Vogt BA, Jones AK Pain and Stroop interference tasks activate separate processing modules in anterior cingulate cortex. Exp Brain Res (Experimentelle Hirnforschung Experimentation cerebrale). 1998; 118:(1)52-60
Davis KD, Moayedi M Central mechanisms of pain revealed through functional and structural MRI. J Neur Pharm. 2013; 8:(3)518-534
Pecina M, Azhar H, Love TM, Lu T, Fredrickson BL, Stohler CS Personality trait predictors of placebo analgesia and neurobiological correlates. Neuropsychopharmacology. 2013; 38:(4)639-646

Pain part 1: introduction to pain

From Volume 42, Issue 2, March 2015 | Pages 109-124

Authors

Tara Renton

BDS, MDSc, PhD

Professor of Oral Surgery, King's College London; Honorary Consultant in Oral Surgery, King's College Hospital NHS Foundation Trust and Guy's and St Thomas' NHS Foundation Trust, London

Articles by Tara Renton

Abstract

This series of papers aims to provide the dental and medical teams with an update in pain, both acute and chronic orofacial conditions, relevant to dentistry and medicine. Pain is the most common symptom for patients presenting to their dentist, and is increasingly commonly presenting to doctors as well, in general practice and A & E departments. Most of the dental team take for granted their knowledge and ability to manage acute dental pain. However, the education and preparation in managing patients with chronic pain conditions remains poor in many medical and dental schools. Conversely, medics are better educated and exposed to chronic pain during their undergraduate education, however, with regards to orofacial pain education, exposure is diminishing due to decreased exposure to dentistry, ENT, otolaryngology, OMFS and oral surgery. Thus many clinical teams remain disadvantaged when diagnosing and managing orofacial pain.

Clinical Relevance: Significant advances that have been made in understanding the pain mechanisms are not to be overlooked and have a huge impact on how we manage patients in pain.

Article

The Greek goddess of revenge, ‘Poine’, was sent to punish the mortal fools who had angered the gods. This gave us our word pain. Many ancient cultures believed pain and disease were punishment for human folly, resulting in many ‘pain-inducing rituals in ancient cultures’. Most people dealt with pain using some derivative of opium (first reported c5000 BCE). Opium is a Middle English word (c1100–c1500 AD) of Greek origin that passed through Latin into English. Opium is a diminutive of the ancient Greek opos, or milky juice of plants. Few reports of attempts were made to understand the mechanisms of pain. Galen (129–216) was the first to describe a network of nerves leading to the brain. Later, Mairnonides (1138–1204), a Spanish philosopher residing in Egypt, reported that ‘Galen's art heals only the body but Abou Amran's (Mairnonides) heals the body and soul’. Later, Descartes (1596–1650) was the first to state that pain was experienced in the brain, rather than in the heart, as the accepted Aristotelian doctrine. Patrick Wall and Ron Melzack's 1965 gate theory of pain1 was a breakthrough, based on our better understanding of pain pathways in man.

Register now to continue reading

Thank you for visiting Dental Update and reading some of our resources. To read more, please register today. You’ll enjoy the following great benefits:

What's included

  • Up to 2 free articles per month
  • New content available