References

Challacombe SJ, Osailan SMPG. Clinical scoring scales for assessment of dry mouth. In: Carpenter G (ed). Berlin: Springer; 2015
Thomson WM, van der Putten GJ, de Baat C Shortening the xerostomia inventory. Oral Surg Oral Med Oral Pathol Oral Radiol Endo. 2011; 112:322-327 https://doi.org/10.1016/j.tripleo.2011.03.024
King's College London. The Challacombe scale. http://www.challacombescale.co.uk/index.html (accessed November 2022)
Ching AS, Ahuja AT. High-resolution sonography of the submandibular space: anatomy and abnormalities. AJR Am J Roentgenol. 2002; 179:703-708 https://doi.org/10.2214/ajr.179.3.1790703
French K, Fleming C, Bell C, Staines K. Labial gland biopsy: shared care, medicolegal and surgical considerations. Oral Surgery. 2019; 12:(3)189-197
Fisher BA, Jonsson R, Daniels T Standardisation of labial salivary gland histopathology in clinical trials in primary Sjögren's syndrome. Ann Rheum Dis. 2017; 76:1161-1168 https://doi.org/10.1136/annrheumdis-2016-210448
Agha-Hosseini F, Moosavi MS. An evidence-based review literature about risk indicators and management of unknown-origin xerostomia. J Dent (Tehran). 2013; 10:273-282
NICE. Dental checks: intervals between oral health reviews. http://www.nice.org.uk/guidance/cg19/chapter/Introduction (accessed November 2022)
NHS England. Delivering better oral health: an evidence-based toolkit for prevention. 2021. http://www.gov.uk/government/publications/delivering-better-oral-health-an-evidence-based-toolkit-for-prevention (accessed November 2022)
Cassolato SF, Turnbull RS. Xerostomia: clinical aspects and treatment. Gerodontology. 2003; 20:64-77 https://doi.org/10.1111/j.1741-2358.2003.00064.x
Furness S, Worthington HV, Bryan G Interventions for the management of dry mouth: topical therapies. Cochrane Database Syst Rev. 2011; (12) https://doi.org/10.1002/14651858.CD008934.pub2
Jawad H, Hodson NA, Nixon PJ. A review of dental treatment of head and neck cancer patients, before, during and after radiotherapy: part 2. Br Dent J. 2015; 218:(2)69-74 https://doi.org/10.1038/sj.bdj.2015.29
Simons D, Kidd EA, Beighton D, Jones B. The effect of chlorhexidine/xylitol chewing-gum on cariogenic salivary microflora: a clinical trial in elderly patients. Caries Res. 1997; 31:91-96 https://doi.org/10.1159/000262382
Nadig SD, Ashwathappa DT, Manjunath M A relationship between salivary flow rates and Candida counts in patients with xerostomia. J Oral Maxillofac Pathol. 2017; 21 https://doi.org/10.4103/jomfp.JOMFP_231_16
Garcia-Cuesta C, Sarrion-Pérez MG, Bagán JV. Current treatment of oral candidiasis: a literature review. J Clin Exp Dent. 2014; 6:e576-582 https://doi.org/10.4317/jced.51798
British National Formulary. 2022. https://bnf.nice.org.uk (accessed November 2022)
British National Formulary. Fluconazole. Interactions. 2022. https://bnf.nice.org.uk/interactions/fluconazole/ (accessed November 2022)
Akpan A, Morgan R. Oral candidiasis. Postgrad Med J. 2002; 78:455-459 https://doi.org/10.1136/pmj.78.922.455
British National Formulary. Miconazole. Interactions. 2022. https://bnf.nice.org.uk/interaction/miconazole-2.html
Bogucki ZA. Denture adhesives' effect on retention of prostheses in patients with xerostomia. Adv Clin Exp Med. 2018; 27:1247-1252 https://doi.org/10.17219/acem/69078
Isidor F, Brøndum K, Hansen HJ Outcome of treatment with implant-retained dental prostheses in patients with Sjögren syndrome. Int J Oral Maxillofac Implants. 1999; 14:736-743
Payne AG, Lownie JF, Van Der Linden WJ. Implant-supported prostheses in patients with Sjögren's syndrome: a clinical report on three patients. Int J Oral Maxillofac Implants. 1997; 12:679-685
Chainani-Wu N, Gorsky M, Mayer P Assessment of the use of sialogogues in the clinical management of patients with xerostomia. Spec Care Dentist. 2006; 26:164-170 https://doi.org/10.1111/j.1754-4505.2006.tb01719.x
Gorsky M, Epstein JB, Parry J The efficacy of pilocarpine and bethanechol upon saliva production in cancer patients with hyposalivation following radiation therapy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004; 97:190-195 https://doi.org/10.1016/j.tripleo.2003.08.031
Fife RS, Chase WF, Dore RK Cevimeline for the treatment of xerostomia in patients with Sjögren syndrome: a randomized trial. Arch Intern Med. 2002; 162:1293-1300 https://doi.org/10.1001/archinte.162.11.1293
Assy Z, Brand HS. A systematic review of the effects of acupuncture on xerostomia and hyposalivation. BMC Complement Altern Med. 2018; 18 https://doi.org/10.1186/s12906-018-2124-x
Furness S, Bryan G, McMillan R Interventions for the management of dry mouth: non-pharmacological interventions. Cochrane Database Syst Rev. 2013; 2013:(9) https://doi.org/10.1002/14651858.CD009603.pub3
Ship JA, McCutcheon JA, Spivakovsky S, Kerr AR. Safety and effectiveness of topical dry mouth products containing olive oil, betaine, and xylitol in reducing xerostomia for polypharmacy-induced dry mouth. J Oral Rehabil. 2007; 34:724-732 https://doi.org/10.1111/j.1365-2842.2006.01718.x
Rantanen I, Nicander I, Jutila K Betaine reduces the irritating effect of sodium lauryl sulfate on human oral mucosa in vivo. Acta Odontol Scand. 2002; 60:306-310 https://doi.org/10.1080/00016350260248292
Pretty IA, Gallagher MJ, Martin MV A study to assess the effects of a new detergent-free, olive oil formulation dentifrice in vitro and in vivo. J Dent. 2003; 31:327-332 https://doi.org/10.1016/s0300-5712(03)00052-6

Xerostomia: Part 2. investigations and management

From Volume 49, Issue 11, December 2022 | Pages 873-878

Authors

Farima Mehrabi

BDS, MFDS, RCSEd PgCertMedEd

Dental Foundation Trainee

Articles by Farima Mehrabi

Dáire Shanahan

BA BDentSc, MBBCh, MFDRCSI

Specialist Trainee in Oral Medicine, University of Bristol Dental Hospital

Articles by Dáire Shanahan

Gemma Davis

BDS, MFDSRCS (Eng), PgCertTLHP

Specialty Registrar in Oral Medicine, University Hospitals Bristol NHS Foundation Trust, Bristol, UK

Articles by Gemma Davis

Abstract

Xerostomia is the subjective sensation of a dry mouth. It can negatively impact oral health and quality of life. This article reviews the investigations and management of xerostomia. Early recognition and management of xerostomia is important to limit the adverse effects that can be caused by this condition.

CPD/Clinical Relevance: Awareness of the possible aetiologies and oral manifestations of xerostomia are important for the general dental practitioner.

Article

In the first part of this two-part series on xerostomia, or dry mouth, the aetiology and oral manifestations were explored, with particular attention being paid to the impact dry mouth can have on both a patient's oral health and their oral health-related quality of life. In Part 2, its diagnosis and symptom management are discussed.

When diagnosing xerostomia a thorough history should be obtained from the patient in order to establish the duration and severity of their symptoms, as well as the impact on the patient's quality of life. The history should then be focused to try and identify any potential underlying causes, such as associated systemic diseases including diabetes mellitus and rheumatological conditions that may raise the suspicion of Sjögren's syndrome. A comprehensive drug history should then follow to identify whether the patient is taking any medications that are implicated in inducing xerostomia. A social history including smoking status, alcohol consumption and illicit drug use should also be taken.

Register now to continue reading

Thank you for visiting Dental Update and reading some of our resources. To read more, please register today. You’ll enjoy the following great benefits:

What's included

  • Up to 2 free articles per month
  • New content available