Laukkanen E, Vehkalahti MM, Kotiranta AK. Impact of systemic diseases and tooth-based factors on outcome of root canal treatment. Int Endod J. 2019; 52:1417-1426 https://doi.org/10.1111/iej.13143
Winning L, Linden G. Periodontitis and systemic disease. BDJ Team. 2015; 2
Aminoshariae A, Kulild JC, Fouad AF. The impact of endodontic infections on the pathogenesis of cardiovascular disease(s): a systematic review with meta-analysis using GRADE. J Endod. 2018; 44:1361-1366.e3 https://doi.org/10.1016/j.joen.2018.06.011
Cotti E, Dessì C, Piras A Association of endodontic infection with detection of an initial lesion to the cardiovascular system. J Endod. 2011; 37:1624-1629 https://doi.org/10.1016/j.joen.2011.09.006
Wang CH, Chueh LH, Chen SC Impact of diabetes mellitus, hypertension, and coronary artery disease on tooth extraction after nonsurgical endodontic treatment. J Endod. 2011; 37:1-5 https://doi.org/10.1016/j.joen.2010.08.054
Ng YL, Mann V, Gulabivala K. A prospective study of the factors affecting outcomes of non-surgical root canal treatment: part 2: tooth survival. Int Endod J. 2011; 44:610-625 https://doi.org/10.1111/j.1365-2591.2011.01873.x
Liljestrand JM, Mäntylä P, Paju S Association of endodontic lesions with coronary artery disease. J Dent Res. 2016; 95:1358-1365 https://doi.org/10.1177/0022034516660509
Cotti E, Mercuro G. Apical periodontitis and cardiovascular diseases: previous findings and ongoing research. Int Endod J. 2015; 48:926-932 https://doi.org/10.1111/iej.12506
Hex N, Bartlett C, Wright D Estimating the current and future costs of Type 1 and Type 2 diabetes in the UK, including direct health costs and indirect societal and productivity costs. Diabet Med. 2012; 29:855-862 https://doi.org/10.1111/j.1464-5491.2012.03698.x
López-López J, Jané-Salas E, Estrugo-Devesa A Periapical and endodontic status of type 2 diabetic patients in Catalonia, Spain: a cross-sectional study. J Endod. 2011; 37:598-601 https://doi.org/10.1016/j.joen.2011.01.002
Fouad AF, Burleson J. The effect of diabetes mellitus on endodontic treatment outcome: data from an electronic patient record. J Am Dent Assoc. 2003; 134:43-51 https://doi.org/10.14219/jada.archive.2003.0016
Britto LR, Katz J, Guelmann M, Heft M. Periradicular radiographic assessment in diabetic and control individuals. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003; 96:449-452 https://doi.org/10.1016/s1079-2104(03)00034-9
Segura-Egea JJ, Martín-González J, Cabanillas-Balsera D Association between diabetes and the prevalence of radiolucent periapical lesions in root-filled teeth: systematic review and meta-analysis. Clin Oral Investig. 2016; 20:1133-1141 https://doi.org/10.1007/s00784-016-1805-4
Marotta PS, Fontes TV, Armada L Type 2 diabetes mellitus and the prevalence of apical periodontitis and endodontic treatment in an adult Brazilian population. J Endod. 2012; 38:297-300 https://doi.org/10.1016/j.joen.2011.11.001
Arya S, Duhan J, Tewari S Healing of apical periodontitis after nonsurgical treatment in patients with type 2 diabetes. J Endod. 2017; 43:1623-1627 https://doi.org/10.1016/j.joen.2017.05.013
Orstavik D, Kerekes K, Eriksen HM. The periapical index: a scoring system for radiographic assessment of apical periodontitis. Endod Dent Traumatol. 1986; 2:20-34 https://doi.org/10.1111/j.1600-9657.1986.tb00119.x
Oscar P, López A, Lizama A Radiographic characteristics in the periapical healing post endodontic treatment in patients of the Autonomous University of Yucatan, School of Dentistry. Nova Scientia. 2018; 10:379-390
Smadi L. Apical periodontitis and endodontic treatment in patients with type II diabetes mellitus: comparative cross-sectional survey. J Contem Dent Pract. 2017; 18:358-362
Alley BS, Buchanan TH, Eleazer PD. Comparison of the success of root canal therapy in HIV/AIDS patients and non-infected controls. Gen Dent. 2008; 56:155-157
Shetty K, Garcia J, Leigh J. Success of root canal therapy in HIV-positive patients. Gen Dent. 2006; 54:397-402
Drake MT, Clarke BL, Khosla S. Bisphosphonates: mechanism of action and role in clinical practice. Mayo Clin Proc. 2008; 83:1032-1045 https://doi.org/10.4065/83.9.1032
Marx RE. Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. J Oral Maxillofac Surg. 2003; 61:1115-1117 https://doi.org/10.1016/s0278-2391(03)00720-1
Hsiao A, Glickman G, He J. A retrospective clinical and radiographic study on healing of periradicular lesions in patients taking oral bisphosphonates. J Endod. 2009; 35:1525-1528 https://doi.org/10.1016/j.joen.2009.07.020
Imura N, Pinheiro ET, Gomes BP The outcome of endodontic treatment: a retrospective study of 2000 cases performed by a specialist. J Endod. 2007; 33:1278-1282 https://doi.org/10.1016/j.joen.2007.07.018
Interactions between systemic and oral diseases have been investigated in many contexts. This is a narrative review discussing the impact of several systemic diseases, including cardiovascular disease and diabetes mellitus, on non-surgical endodontic treatment outcomes. There is currently a lack of conclusive evidence to support links between systemic disease and endodontic outcomes. Further high-quality research is needed for systemic disease to be reliably considered a prognostic factor.
CPD/Clinical Relevance: If systemic disease is found to impact upon non-surgical endodontic treatment outcomes, dentists could learn essential information regarding the prognosis of endodontic treatment by looking at a patient's medical history.
Article
Endodontology is the study of disease, prevention and treatment of the dental pulp and peri-radicular regions, with the principle disease being apical periodontitis caused by infection.1 Diseases of pulpal origin can severely affect quality of life through physical and psychological discomfort.2 Endodontic treatment offers a solution to treat pulpal disease and avoid the loss of natural teeth.
Success rates for endodontic treatments are high; however, multiple factors can affect outcome, such as the presence or extent of peri-radicular disease, amount of remaining tooth structure and the treatment methods used.3 While some of these factors can be modified, the patient's medical history needs further consideration. A key question that has arisen is whether a patient's systemic disease can affect the success of endodontic treatment outcomes.4 The direct impact of systemic disease on endodontic treatment outcomes has not been conclusively determined and is currently not well understood.
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