Article: Volume 34 Number 5 Page 290 - June 2007
Dental Update 345: 290-294 
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Oral medicine: Focal Palmoplantar and Gingival Hyperkeratosis: A Case Report
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Abstract: We report a rare genetic condition characterized by gingival hyperkeratosis with skin changes affecting the hands and feet. The patient presented with asymptomatic oral lesions and the diagnosis was reached by taking a full clinical history and biopsy tests. Palmoplantar keratosis can be a feature of a range of different syndromes and can be associated with periodontal destruction, benign oral keratosis or cancer of the oesophagus. It is important for dentists to be aware that clues to diagnosis can be gained from examination of the hands and feet, in addition to an oral examination, particularly in recognizing oral genetic disorders.
Clinical relevance: To inform clinicians of both the intra-oral and extra-oral features of focal palmoplantar and gingival hyperkeratosis.
Author notes: Jadbinder Seehra, BDS(Hons), MFDS RCS(Eng), Senior House Officer, Unit of Oral Medicine, Nalin Thakker, BDS, MSc, PhD, FRCPath, Professor of Molecular Pathology and Genetics/Consultant Oral Pathologist, A John Duxbury, BDS, MSc, PhD, DDS, FDS RCPS, FDS RCS, Consultant/Honorary Senior Lecturer in Oral Medicine, Philip Sloan, BDS, PhD, FDS RCS(Eng), FRCPath, Professor of Experimental Oral Pathology, Senathirajah Ariyaratnam, BDS MDS, FDS RCS(Eng), Specialist in Oral Medicine and Surgical Dentistry, The School of Dentistry, University of Manchester, Higher Cambridge Street, Manchester, M15 6FH, UK.
Objective: To highlight the range of oral diseases associated with palmoplantar keratosis and show the importance of taking a full clinical family history.
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