References

Tan ECK, Lexomboon D, Sandborgh-Englund G Medications that cause dry mouth as an adverse effect in older people: a systematic review and metaanalysis. J Am Geriatr Soc. 2018; 66:76-84 https://doi.org/10.1111/jgs.15151
Riley P, Glenny AM, Hua F, Worthington HV. Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy. Cochrane Database Syst Rev. 2017; 7 https://doi.org/10.1002/14651858.CD012744
Percival RS, Challacombe SJ, Marsh PD. Flow rates of resting whole and stimulated parotid saliva in relation to age and gender. J Dent Res. 1994; 73:1416-1420 https://doi.org/10.1177/00220345940730080401
Inoue H, Ono K, Masuda W Gender difference in unstimulated whole saliva flow rate and salivary gland sizes. Arch Oral Biol. 2006; 51:1055-1060 https://doi.org/10.1016/j.archoralbio.2006.06.010
Affoo RH, Foley N, Garrick R Meta-analysis of salivary flow rates in young and older adults. J Am Geriatr Soc. 2015; 63:2142-2151 https://doi.org/10.1111/jgs.13652
Gupta A, Epstein JB, Sroussi H. Hyposalivation in elderly patients. J Can Dent Assoc. 2006; 72:841-846
Åstrøm AN, Lie SA, Ekback G Self-reported dry mouth among ageing people: a longitudinal, cross-national study. Eur J Oral Sci. 2019; 127:130-138 https://doi.org/10.1111/eos.12601
Leite RS, Marlow NM, Fernandes JK, Hermayer K. Oral health and type 2 diabetes. Am J Med Sci. 2013; 345:271-273 https://doi.org/10.1097/MAJ.0b013e31828bdedf
Patel R, Shahane A. The epidemiology of Sjögren's syndrome. Clin Epidemiol. 2014; 6:247-55 https://doi.org/10.2147/CLEP.S47399
Price EJ, Rauz S, Tappuni AR The British Society for Rheumatology guideline for the management of adults with primary Sjögren's Syndrome. Rheumatology (Oxford). 2017; 56:1643-1647 https://doi.org/10.1093/rheumatology/kex163
Bartoloni E, Baldini C, Schillaci G Cardiovascular disease risk burden in primary Sjögren's syndrome: results of a population-based multicentre cohort study. J Intern Med. 2015; 278:185-192 https://doi.org/10.1111/joim.12346
Ramos-Casals M, Brito-Zerón P, Bombardieri S EULAR recommendations for the management of Sjögren's syndrome with topical and systemic therapies. Ann Rheum Dis. 2020; 79:3-18 https://doi.org/10.1136/annrheumdis-2019-216114
Shiboski CH, Shiboski SC, Seror R 2016 American College of Rheumatology/European League Against Rheumatism classification criteria for primary Sjögren's syndrome: a consensus and data-driven methodology involving three international patient cohorts. Ann Rheum Dis. 2017; 76:9-16 https://doi.org/10.1136/annrheumdis-2016-210571
Osailan S, Pramanik R, Shirodaria S, Challacombe SJ, Proctor GB. Investigating the relationship between hyposalivation and mucosal wetness. Oral Dis. 2011; 17:109-114 https://doi.org/10.1111/j.1601-0825.2010.01715.x
Tooyama H, Matsumoto T, Hayashi K Candida concentrations determined following concentrated oral rinse culture reflect clinical oral signs. BMC Oral Health. 2015; 15 https://doi.org/10.1186/s12903-015-0138-z
Jousse-Joulin S, Gatineau F, Baldini C Weight of salivary gland ultrasonography compared to other items of the 2016 ACR/EULAR classification criteria for primary Sjögren's syndrome. J Intern Med. 2020; 287:180-188 https://doi.org/10.1111/joim.12992
Public Health England/Department of Health and Social Care. Delivering better oral health: An evidence-based toolkit for prevention. 2017. http://www.gov.uk/government/publications/delivering-better-oral-health-an-evidence-based-toolkit-for-prevention (accessed September 2021)
Deeming GM, Collingwood J, Pemberton MN. Methotrexate and oral ulceration. Br Dent J. 2005; 198:83-85 https://doi.org/10.1038/sj.bdj.4811972

Authors

Shalini Nayee

BDS(Hons), MSc, MBBS

NIHR Academic Clinical Fellow in Oral Medicine, Guy's Hospital, London

Articles by Shalini Nayee

Cameron Herbert

BDS, MBBS

Specialty Registrar in Oral Medicine, Guy's Hospital, London

Articles by Cameron Herbert

Pepe Shirlaw

BDS, FDS, RCPS

Consultant in Oral Medicine, Guy's Hospital, London

Articles by Pepe Shirlaw

Richard Cook

BDS, FDS, PhD

Professor and Honorary Consultant in Oral Medicine, King's College London

Articles by Richard Cook

Email Richard Cook

Abstract

Dry mouth has numerous causes, including medications, radiotherapy and rheumatological conditions, such as Sjögren's syndrome. This article presents the common causes of dry mouth, and details the assessment, investigations and management required for patients with dry mouth within primary dental care, in addition to outlining secondary care investigations and management.

CPD/Clinical Relevance: Dry mouth is common in the general population, with widespread implications for dental health and patients' quality of life. Dental professionals have a key role in both its identification and long-term management.

Article

Dry mouth is a common presentation in the dental clinic, requiring thorough assessment and management, both for short-term comfort and long-term disease monitoring and prevention of secondary consequential disease. The causes of dry mouth may be local, systemic or idiopathic; however, irrespective of the underlying cause, maintenance of oral health and prevention of dental disease should underpin management within primary care. Loss of the oral cleansing, antimicrobial, lubricating and buffering capacity of saliva can cause a multitude of problems, including increased susceptibility to dental caries, periodontal disease, mucosal trauma and oral candidosis. Patients may report a deleterious impact on their quality of life, reporting oral discomfort or burning, impaired eating and difficulties with speech.

This article reviews the common causes of dry mouth, the relevant investigations and possible treatment options available.

The perceived sensation of dry mouth in the context of normal unstimulated and stimulated salivary flow rates is referred to as subjective xerostomia. Changes in the qualitative nature of saliva may contribute towards these symptoms, as can mouth breathing. Subjective xerostomia may also occur as part of conditions such as oral dysaesthesia and burning mouth syndrome. Symptomatic management of dry mouth symptoms may contribute towards an overall improvement in the patient's dysaesthetic symptoms.

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