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References

Fareed WM, Tandon P, Ahmad EZ Efficacy of blood and its products – boon for oral surgeons: review. J Univers Sur. 2017; 5:1-7
Tsay RC, Jennifer V, Burke A Differential growth factor retention by platelet rich plasma. J Oral Maxillofac Surg. 2005; 63:521-528
Albanese A, Licata ME, Polizzi B, Campisi G. Platelet-rich plasma (PRP) in dental and oral surgery: from the wound healing to bone regeneration. Immun Ageing. 2013; 10 https://doi.org/10.1186/1742-4933-10-23
Pietrzak WS, Eppley BL. Platelet rich plasma: biology and new technology. J Craniofac Surg. 2005; 16:1043-1054
Gonshor A. Technique for producing platelet-rich plasma and platelet concentrate: background and process. Int J Periodont Rest Dent. 2002; 31:615-619
Choukroun J, Diss A, Simonpieri A Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part III: leucocyte activation: a new feature for platelet concentrates. Oral Surg Oral Med Oral Pathol Oral Radiol Endodont. 2006; 101:e51-e55
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Narang I, Mittal N, Mishra N. A comparative evaluation of the blood clot, platelet-rich plasma, and platelet rich fibrin in regeneration of necrotic immature permanent teeth: a clinical study. Contemp Clin Dent. 2015; 6:63-68
Antoniades HN, Galanopoulous T, Neville-Golden J, Kiritsy CP, Lunch SE. Expression of growth factor and receptor mRNA in skin epithelial cells following acute cutaneous injury. Am J Pathol. 1993; 142:1099-1110
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Panda S, Ramamoorhi S, Jayakumar ND, Sankari M, Varghese SS. Platelet rich fibrin and alloplast in the treatment of intrabony defect. J Pharm BioAll Sci. 2014; 6:127-131
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Hanna R, Trejo PM, Weltman RL. Treatment of intrabony defects with bovine-derived xenograft alone and in combination with platelet-rich plasma: a randomized clinical trial. J Periodont. 2004; 75:1668-1677
Padma R, Shilpa A, Kumar PA A split mouth randomised controlled trial to evaluate the adjunctive effect of platelet-rich fibrin to coronally repositioned flaps in Miller's class-I and II recession defects. J Ind Soc Periodontol. 2013; 17:631-636
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Autologous blood products and their role within dentistry

From Volume 46, Issue 7, July 2019 | Pages 676-683

Authors

Arif Razzak

BDS, MFDS, PgDip MedEd, DCT2

Queen's Medical Centre DCT1, Derby Road, Nottingham NG7 2UH, UK

Articles by Arif Razzak

Sarah Jenkins

BDS, MFDS

Oral and Maxillofacial Specialty Doctor, UK

Articles by Sarah Jenkins

Keith Smart

BDS, FFD RCSIre

Oral Surgery Consultant, Prince Charles Hospital, Merthyr Tydfil, CF47 9DT, UK

Articles by Keith Smart

Abstract

Use of autologous blood products, such as platelet rich plasma (PRP) and platelet rich fibrin (PRF) is increasing within the field of dentistry. Such products aim to promote bone regeneration which is valuable in a range of procedures, including implant placement, post tooth extraction, and periodontal surgery. Dental practitioners should be aware of what these new materials are, and the beneficial role that they may play in modern dentistry.

CPD/Clinical Relevance: This article aims to inform the reader regarding the range of available autologous blood products, their uses in dentistry, how they are derived from whole blood, as well as cost and time implications.

Article

Blood comprises various components, which can be classified into ‘formed’ elements (red blood cells, white blood cells and platelets), and plasma elements (such as fibrinogen, water and albumin).1 Blood not only transports oxygen from the lungs to the tissues, it also has a vital role in the transportation and storage of various nutrients and toxins, aids homeostasis and regenerative processes.2,3 Techniques exist in which blood is separated out into its different parts, enabling components that aid regeneration to be harnessed and used to aid dental treatments.

These products are becoming more widely used within medical fields whereby patients have local injections of blood products. This is being used in the treatment of osteoarthritis, and some bodies recommend its use for facial cosmetics, however, currently there is an ongoing debate about its effectiveness in this role.

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