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Article: Volume 49 Number 1 Page 69 - January 2022

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  Dental Update 496: 69-73

Endodontics:  Impact of Systemic Disease on Non-surgical Endodontic Treatment Outcomes

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Abstract: Interactions between systemic and oral diseases have been investigated in many contexts. This is a narrative review discussing the impact of several systemic diseases, including cardiovascular disease and diabetes mellitus, on non-surgical endodontic treatment outcomes. There is currently a lack of conclusive evidence to support links between systemic disease and endodontic outcomes. Further high-quality research is needed for systemic disease to be reliably considered a prognostic factor.

Clinical relevance: If systemic disease is found to impact upon non-surgical endodontic treatment outcomes, dentists could learn essential information regarding the prognosis of endodontic treatment by looking at a patient’s medical history.

Author notes: Basma Salem, BDS (QUB), MRes, Dental Core Trainee in Oral and Maxillofacial Surgery, Royal United Hospitals, Bath. Gerry McKenna, BDS, MFDS RCSEd, PhD, PgDipTLHE, FDS (Rest Dent) RCSEd, FHEA, FDTFEd, Senior Lecturer/Consultant in Restorative Dentistry, Queen’s University, Belfast. Graham Quilligan BDS, NUI, MFDS RCSEd, MSc(Endo) UCL, PGCTLHE, Consultant in Restorative Dentistry (Endodontics), Cork University Dental School and Hospital, Ireland. email:

Objective: To update readers on linkages between systemic disease and non-surgical endodontic treatment outcomes.

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