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Article: Volume 41 Number 9 Page 796 - November 2014

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  Dent Update 2014; 41: 796-810

Periodontology:  Local Drug Delivery in the Management of Periodontal Diseases Part 2: Specific Agents

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Abstract: Local drug delivery systems (LDDs) are mainly used as adjuncts to root surface instrumentation (RSI) in the management of periodontal disease. A range of antibacterial agents have been used for this purpose and include the tetracyclines, chlorhexidine, metronidazole, azithromycin, clarithromycin and moxifloxacin. More recently, other non-antibacterial agents have been incorporated into local delivery devices and include simvastatin, metformin and alendronate. This paper will review the effectiveness of such agents when used as an adjunct to conventional non-surgical periodontal therapy.

Clinical relevance: The benefits of adjunctive use of local drug delivery in the management of periodontal disease will be discussed.

Author notes: Jane E Eastham, BDS(Hons), Research Assistant, School of Dental Sciences and Robin A Seymour, BDS, FDS RCS, FDS RCS(Edin), PhD, FHKAMS, Emeritus Professor of Restorative Dentistry, School of Dental Sciences, Newcastle University, Framlington Place, Newcastle Upon Tyne, NE2 4BW, UK.

Objective: To evaluate the evidence of the adjunctive use of local drug delivery systems.