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Article: Volume 49 Number 4 Page 301 - April 2022

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  Dental Update 499: 301-306

Periodontology:  Enamel Matrix Derivative Use in Dentistry: An Update

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Abstract: Following a review of periodontal wound healing, this article discusses techniques designed to optimise periodontal wound healing, including guided-tissue regeneration and periodontal regeneration using enamel matrix derivatives. Enamel matrix derivatives are porcine derived, and are thought to stimulate differentiation, proliferation, migration and mineralization in cells found in periodontal tissues. This article charts the development in surgical techniques to optimise outcomes from regenerative techniques, in addition to explaining complications and how they can be avoided. Recent research relating to use of enamel matrix derivatives as an adjunct to non-surgical periodontal therapy is described, and while the evidence is limited to a single research study, the present article discusses the potential use of this technique in practice, accepting that a cost–benefit analysis would be required for individual patients.

Clinical relevance: An update for practitioners on developments in use of enamel matrix derivatives in dentistry to allow informed decision-making on the utility and value of using flapless techniques.

Author notes: Michael Daldry, BSc(Hons), BDS(Hons), Foundation Dentist, Dental Centre, Bournemouth. Jaini Shah, BDS, Foundation Dentist, Poynters Road Dental Practice, Dunstable. Ewen McColl, BSc(Hons), BDS, MFDS, FDS RCPS, MCGDent, MRD RCS Ed, MClinDent, FDS RCS(Rest Dent), FHEA, FDTF(Ed), Director of Clinical Dentistry, Peninsula Dental School, University of Plymouth. Rob Witton, MPH, BDS, DPDS, MFDSRCS(Eng), FDS(DPH), RCS(Eng), MFGDP(UK), CertPerio, FDTF(Ed), FHEA. Director of Community-based Dentistry, Peninsula Dental School, University of Plymouth.

Objective: To reinforce the importance of periodontal screening in children and adolescents and discuss the need for appropriate referral to secondary care.

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