Article: Volume 41 Number 8 Page 732 - October 2014

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  Dent Update 2014; 41: 732-736

Periodontology:  Local Drug Delivery in the Management of Periodontal Diseases Part 1: General Principles

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Abstract: Periodontal pockets provide an ideal environment for the application of local drug delivery for the management of periodontitis. In this first article, consideration is given to the principles that underlie local drug delivery and the pharmacological challenges. It is essential that such systems are compatible with the periodontal tissues. Potential unwanted effects that can arise from both drug and delivery vehicle are also appraised.

Clinical relevance: Local drug delivery systems still have a place in the management of periodontal diseases. This first article considers the pharmacological principles and unwanted effects that can arise from the use of such systems.

Author notes: Jane E Eastham, BDS(Hons), Research Assistant, Robin A Seymour, BDS, FDS RCS, FDS RCS(Edin), PhD, FHKAMS, Professor of Restorative Dentistry, School of Dental Sciences, Newcastle University, Framlington Place, Newcastle Upon Tyne, NE2 4BW, UK.

Objective: To understand the principles and challenges that arise from the application of local drug delivery systems in the management of periodontal disease.

ADG